http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010511698-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 |
| filingDate | 2007-12-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-04-15^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2010511698-A |
| titleOfInvention | 7-Hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline derivatives having preventive and therapeutic effects on degenerative and inflammatory diseases |
| abstract | The present invention relates to a novel compound, 7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline (HMTIQ) derivative and a process for producing the same, wherein the compound is activated nitric oxide (NO) and Remarkably suppress the increase of superoxide, suppress the gene expression of TNF-α, IL-1β, inducible nitric oxide synthase and cyclooxygenase-2, suppress the transfer of NF-kB to the nucleus, and react Reduces the production of oxidants (ROS), suppresses GTP cyclohydrolase I gene expression and tetrahydrobiopterin (BH4) overproduction and significantly protects active microglia from damage to dopaminergic neurons Represents. As a result, the newly synthesized compound of the present invention has an effect as a drug for treating inflammatory diseases and degenerative neurological diseases. |
| priorityDate | 2006-12-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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