abstract |
The present invention provides compositions and methods useful for treating and preventing neurodegenerative diseases and neurological disorder relating to the inhibition of Lp-PLA 2. The compositions and methods may be used to treat diseases and disorders with abnormal blood brain barrier (BBB) function, such as neurodegenerative diseases with permeable BBB, such as, but not limited to, Alzheimer's disease, Huntington's disease, Parkinson's disease and vascular Useful for treating and preventing dementia. |