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filingDate 2008-04-14^^<http://www.w3.org/2001/XMLSchema#date>
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publicationNumber JP-2010531295-A
titleOfInvention Microfluidic Radiosynthesis System for Positron Emission Tomography Biomarkers (Related Application) This application is a US Provisional Application No. 60 / 923,086 filed Apr. 12, 2007, April 2007. U.S. Provisional Application No. 60 / 923,407 filed on Jan. 13, U.S. Patent Provisional Application No. 11 / 895,636, filed Aug. 23, 2007, and Jan. 2008 Claims priority based on US Provisional Patent Application No. 61 / 010,822, filed on Jan. 11, the contents of each of which are incorporated herein by reference in their entirety.
abstract Disclosed are methods and apparatus for fully automated synthesis of radioactive compounds for imaging in a rapid, efficient and precise manner, for example by positron emission tomography (PET). In particular, the various embodiments of the present invention are PET radioactivity purified within a shorter period of time than a conventional chemical system starting from target water on a microfluidic device with an unlimited flow of gas through the reactor. Provides an automated, independent, hands-free operation of the entire radiosynthesis cycle to produce a tracer Accordingly, one aspect of the present invention provides a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to the reaction chamber, and the inside and outside of the reaction chamber. The invention relates to a microfluidic chip for radiosynthesizing radiolabeled compounds comprising one or more integrated valves for performing flow control. [Selection] Figure 3
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