abstract |
Formula IA or IB useful as Rho kinase inhibitors: And compounds of any tautomer, salt, stereoisomer, hydrate, solvate, prodrug, pharmaceutical composition, method of treatment, and synthesis thereof are provided, wherein in Formulas IA and IB: A, B, D, E, R 1 , R 2 and Ar 1 are as defined herein. In various embodiments, the present invention provides a pharmaceutical combination containing a compound of the present invention and a second medicament. |