| abstract |
The present invention relates to novel compounds, in particular novel indole and benzomorpholine derivatives of formula (I), wherein all radicals in the formula are defined in the present application and claims. The compounds according to the present invention are positive allosteric modulators of metabotropic receptor subtype 2 (“mGluR2”), and are associated with neurological and psychiatric disorders and diseases associated with glutamate dysfunction involving the mGluR2 subtype of metabotropic receptors. Useful for treatment or prevention. Specifically, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression and epilepsy. The present invention is further directed to pharmaceutical compositions, processes for preparing such compounds and compositions, and the use of such compounds in the prevention and treatment of the above-mentioned diseases involving mGluR2. |