| abstract |
Isolated aspartyl tRNA synthetase polypeptides and polynucleotides having non-standard biological activity, and related compositions and methods are provided. In certain embodiments, the non-standard biological activity exhibited by the aspartyl tRNA synthetase polypeptide of the present invention includes modulating cell proliferation, modulating apoptosis, modulating inflammation, modulating cell differentiation, modulating angiogenesis, cells Modulation of binding, regulation of cell signaling via Akt, regulation of cellular metabolism, regulation of cytokine production or activity, regulation of toll-like receptor signaling, and the like. |