| abstract |
The present invention is directed to compounds of formula (I): The present invention provides compounds that inhibit, regulate and / or modulate PI3K and / or mTOR, which are hyperproliferative, such as cancer, in mammals. Useful for the treatment of sexually transmitted diseases. The present invention is also used for methods of making compounds, methods of using such compounds in the treatment of hyperproliferative diseases in mammals, particularly humans, and pharmaceutical compositions containing such compounds. It also provides a way to do this. For example, cancers whose activity against PI3K-alpha, mTOR, or both contribute to its pathology and / or symptoms include breast cancer, mantle cell lymphoma, renal cell carcinoma, acute myeloid leukemia, chronic myeloid leukemia, NPM / ALK-transformed anaplastic large cell lymphoma, diffuse large B cell lymphoma, rhabdomyosarcoma, ovarian cancer, endometrial cancer, cervical cancer, non-small cell lung cancer, small cell lung cancer, adenocarcinoma, colon Cancer, rectal cancer, gastric cancer, hepatocellular carcinoma, melanoma, pancreatic cancer, prostate cancer, thyroid cancer, anaplastic large cell lymphoma, hemangioma, glioblastoma, or head and neck cancer are included. |