| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0886ec31ebb266f07c28875e8ff43a92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_faf522b8b83eded745c73018576219ba |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate |
2012-04-10^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d4af91b4585585d0635a5b4ebc1e770
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bdbc786fda1a634104e39085baae57b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81a9fad09409a1de6adec13c9659f6f7 |
| publicationDate |
2013-10-24^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2013216627-A |
| titleOfInvention |
Apoptosis inducer and cancer therapeutic agent |
| abstract |
An apoptosis inducer and a cancer therapeutic agent having higher therapeutic effects are provided. An siRNA targeting a predetermined partial sequence of a Y box binding protein 1 gene induces apoptosis of vascular endothelial cells. The siRNA inhibits lumen formation by vascular endothelial cells. In addition, the siRNA inhibits neovascularization and causes blood vessels to retreat. The siRNA can suppress abnormal angiogenesis in a tumor site or the like. In addition, the siRNA can destroy excessively formed new blood vessels. For this reason, the siRNA has a higher therapeutic effect on intractable tumors and proliferative vascular diseases. [Selection] Figure 3 |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102014221144-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2016006697-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016006697-A1 |
| priorityDate |
2012-04-10^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |