http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013505294-A

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publicationDate 2013-02-14^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2013505294-A
titleOfInvention Chemical production module for PET biomarker production system and administration liquid synthesis card
abstract A microfluidic radiopharmaceutical manufacturing system and method for synthesizing about 1-4 unit doses of a radiopharmaceutical biomarker per actuation for use in positron emission tomography (PET). The system includes a reaction vessel that receives a radioisotope from an accelerator or other radioisotope generator. An organic reagent and an aqueous reagent are introduced into the reaction vessel, and the mixture is heated to synthesize a preselected radiopharmaceutical solution. The radiopharmaceutical solution is purified by passing it through a solid phase extraction column or filter. This synthesis method reduces waste and makes it possible to produce radiopharmaceuticals as needed. This synthetic method allows for production near the site and location where the unit dose is administered to the patient, thereby reducing the time from synthesis to administration, thereby minimizing loss of active isotopes due to decay. As a whole, a smaller amount of radioisotope can be produced. [Selection] Figure 1
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