| abstract |
The present invention relates to 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxyanilide, their thienopyridone analogs, and compounds that are prodrugs thereof. The present invention relates in particular to such derivatives containing N-hydrogen in the carboxyanilide moiety and exhibiting modulatory activity on the aromatic hydrocarbon receptor (AhR), and in particular also its prodrugs. The invention further relates to the use of the aforementioned compounds as medicaments for the treatment of cancer, autoimmune diseases and other disorders having an immunological component, and pharmaceutical compositions comprising one or more of the aforementioned compounds And a method of treatment. |