| abstract |
An agonist of G protein-coupled receptor TGR5 is provided. [Solution] The present invention includes TGR5 agonists of structural formula I, wherein X, R 1 , R 2 , and R 5 are defined herein, as well as their N oxides and pharmaceutically acceptable salts thereof. The present invention further includes compositions comprising compounds, their N oxides, and / or pharmaceutically acceptable salts thereof. The invention also includes the use of compounds and compositions for treating diseases in which TGR5 is a mediator or is implicated. The invention also includes the use of a compound in or for the manufacture of a medicament for treating a disease in particular where TGR5 is a mediator or is implicated. [Selection figure] None |