| abstract |
The present invention provides a compound that inhibits the activity of anti-apoptotic BcI-2 or BcI-xL protein, and a composition for treating cancer containing the compound. A compound that inhibits the activity of anti-apoptotic BcI-2 or BcI-xL protein represented by formula (I), and bladder cancer, brain tumor, breast cancer, bone marrow cancer, cervical cancer, chronic, comprising the same Lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular carcinoma, lymphoblastic leukemia, follicular lymphoma, lymphoid malignancy derived from T cells or B cells, melanoma, myeloid leukemia, myeloma, oral cancer, A composition for treating ovarian cancer, non-small cell lung cancer, prostate cancer, small cell lung cancer or spleen cancer. [A1 is N, etc .; B1, D1 and E1 are alkoxy groups, etc .; Y1 is H, etc .; Z1 is a substituted phenyl group, etc.] |