| abstract |
Disclosed is a novel diazepine compound which strongly blocks I Kur current or Kv1.5 channel and selectively blocks other K + channels. A diazepine compound represented by the formula (1) or a salt thereof. (R 1 to R 4 are each independently H, lower alkyl, cyclo-lower alkylalkyl, etc .; A 1 is a lower alkylene which may have a substituent selected from hydroxy or oxo; R 5 is the following formula; R 6 and R 7 is each independently H or an organic group; R 6 and R 7 may form a ring with adjacent groups —X A —N—X B —; X A and X B are each independently a bond, lower Alkylene) [Selection figure] None |