| abstract |
Synthetic interfering RNA molecules that are stable and active in a biochemical environment such as a living cell are provided. A ribonucleic acid comprising a double-stranded structure, wherein the double-stranded structure comprises a first strand and a second strand, wherein the first strand comprises a first stretch of contiguous nucleotides, and the first strand One stretch is at least partially complementary to the target nucleic acid and the second strand comprises a second stretch of contiguous nucleotides, wherein the second stretch is at least partially identical to the target nucleic acid And a ribonucleic acid in which the double-stranded structure has a blunt end. [Selection figure] None |