| abstract |
The present invention relates to compounds of formula I, their N-oxides, tautomers, prodrugs and pharmaceutically acceptable salts. In formula I, the variable X 1 is CH or N, X 2 is O or S, and R 1 , R 2 , R 3 , R 4 and Q are as defined in the claims. is there. The compounds of formula I, their N-oxides, tautomers, prodrugs and pharmaceutically acceptable salts are inhibitors of phosphodiesterase type 10A. The invention therefore also relates to the use of the compounds of formula I, their N-oxides, tautomers, prodrugs and pharmaceutically acceptable salts for the manufacture of a medicament. Accordingly, the present invention is suitable for treating or inhibiting a medical disorder selected from neurological and psychiatric disorders, ameliorating symptoms associated with such disorders, and reducing the risk of such disorders. Yes. |