| abstract |
Organic compounds useful for treatment and / or prevention in mammals, particularly Abl tyrosine kinases (eg, c-Abl; ABL1, useful for treating diseases and disorders resulting from overactivation of Abl tyrosine kinase) v-Abl) and related inhibitors of tyrosine kinases (eg, Abl-related gene; ABL2). A novel compound represented by formula (I), a composition containing the compound, and a method of using the composition. (X 1 is N or N + O − ; one of X 2 to X 4 is N or N + O − , the rest is C; R 2 to R 6 are hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, etc. ; -AB is 2-thiophenyl-S (O) 2CH2 or the like) [Selection figure] None |