| abstract |
Provided are peptides and polypeptides that mimic the function of apelin but have an increased half-life and exhibit biological activity equal to or greater than that of naturally occurring apelin. A synthetic polypeptide or an amide, ester, or salt thereof, which is an APJ receptor agonist consisting of amino acids, and includes acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia , Atherosclerosis, hypertension, restenosis, ischemic cardiovascular disease, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular attack, transient Such as treatment or prevention of traumatic brain ischemic attack, traumatic brain injury, amyotrophic lateral sclerosis, burns (including sunburn), and pre-eclampsia It can be used to care. [Selection figure] None |