| abstract |
A method for preparing an oxycodone hydrochloride composition having a lower amount of 14-hydroxycodeinone. Hydrogenating an oxycodone hydrochloride composition having at least 100 ppm of 14-hydroxycodeinone in a suitable solvent such as alcohol using a hydrogen donor such as hydrogen gas, formic acid or indoline and a catalyst, Producing a oxycodone composition having less than 25 ppm of 14-hydroxycodeinone. [Selection figure] None |