| abstract |
Age-modified cells and methods for generating age-modified cells by reducing or increasing the level of genomic nucleic acid methylation in the cells are provided. By reducing or increasing the level of intracellular genomic nucleic acid methylation, somatic cells, stem cells, stem cell-derived somatic cells, including cells derived from induced pluripotent stem cells, And and / or for immature cells, the senescence and / or maturation process can be accelerated or reduced and controlled. By the methods described by the present disclosure, age-appropriate cells such as old cells, young cells, immature cells, and / or mature cells can be produced from somatic cells or stem cells. Such age-modified cells constitute a model system for studying late-onset diseases and / or disorders. [Selection] Figure 1 |