| abstract |
The present invention provides a method of producing a dry vaccine powder formulation that can be used for nasal delivery. The method includes the steps of producing a liquid formulation containing one or more antigens such as a pathogen or component thereof along with one or more substances. The liquid vaccine formulation is freeze dried to produce a powder. The powder can contain microparticles and is stable at room temperature, and when the antigen is an influenza virus, the powder has high HA potency. After freeze-drying, the powder is mixed with one or more excipients to form a dry vaccine powder formulation. 【Selection chart】 None |