http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019512015-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2017-02-24^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2019512015-A |
| titleOfInvention | Modulators for voltage-gated sodium channel Nav1.1 associated with pain due to mechanical stimulation |
| abstract | The present invention provides the use of compounds role in nociception and pain selectively blocks Na v 1.1 subtypes of voltage-gated sodium (Na v) channels are unknown. The present invention demonstrates that Na v 1.1-expressing fibers are modality-specific nociceptors: their activation elicits strong pain behavior without neuropathic inflammation, not thermal stimulation, but mechanical Produces a marked hypersensitivity to a physical stimulus. In the intestine, high threshold mechanical stimuli sensitive fibers also express Na v 1.1 and are more toxin sensitive in models of Irritable Bowel Syndrome. The present invention provides an unexpected role of Na v 1.1 in modulating the excitability of sensory nerve fibers underlying pain due to mechanical stimulation and others that can modulate Na v 1.1 channels. Methods of screening for peptides and small molecules and their use in treating neurological disorders are provided. |
| priorityDate | 2016-02-26^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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