| abstract |
Adrenergic receptor modulating compounds and methods of use thereof are provided. Also provided is a method of treating a subject for a disease or condition associated with an adrenergic receptor comprising administering a therapeutically effective amount of the subject compound. Aspects of the present disclosure include methods of modulating intracellular inflammatory pathways, such as TNF-α production in cells. The method can include contacting a cell with a β1-selective adrenergic receptor modulating compound to selectively activate the cAMP pathway over the β-arrestin pathway in the cell. Pharmaceutical compositions and kits comprising the subject compounds are provided. [Selection] Figure 8 |