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filingDate 2017-10-19^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-12-12^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2019535671-A
titleOfInvention Bromodomain inhibitor
abstract Bromodomain inhibitors 4- [2- (cyclopropylmethoxy) -5-methylsulfonylphenyl] including crystalline forms, amorphous forms, solvates and hydrates thereof, and pharmaceutical compositions comprising the present bromodomain inhibitors -2-Methylisoquinolin-1-one is described herein. In some embodiments, the pharmaceutical composition comprises 4- [2- (cyclopropylmethoxy) -5-methylsulfonylphenyl] -2-methylisoquinolin-1-one that has been processed by micronization or spray-drying dispersion. In some embodiments, the pharmaceutical composition further comprises at least one polymer. In some embodiments, the pharmaceutical composition comprises a solid polymer matrix comprising 4- [2- (cyclopropylmethoxy) -5-methylsulfonylphenyl] -2-methylisoquinolin-1-one and at least one polymer. A pharmaceutical composition comprising 4- [2- (cyclopropylmethoxy) -5-methylsulfonylphenyl] -2-methylisoquinolin-1-one is useful for the treatment of cancer or neoplastic disease.
priorityDate 2016-10-20^^<http://www.w3.org/2001/XMLSchema#date>
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