| abstract |
PROBLEM TO BE SOLVED: To provide a drug conjugate containing a peptide which is a high affinity binder of a membrane type 1 metalloprotease (MT1-MMP). A peptide ligand specific for MT1-MMP, a polypeptide containing at least three cysteine residues separated by at least two loop sequences, and a molecule that forms a covalent bond with the cysteine residue of the polypeptide. It contains TBMB, which is a scaffold, so that at least two polypeptide loops are formed on the molecular scaffold, and the peptide ligand is the amino acid sequence: βAla-Sar10-AC (D-Ala) NE (1Nal) (D-Ala). ) Provide a drug conjugate comprising CEDFYD (tBuGly) C or a pharmaceutically acceptable salt thereof. [Selection diagram] None |