http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021512153-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2019-01-26^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2021512153-A |
| titleOfInvention | Imide-based modulators of proteolysis and how to use |
| abstract | The description relates to imide-based compounds, including bifunctional compounds, including imide-based compounds, which are degraded as targeted ubiquitination modulators, especially by the bifunctional compounds according to the invention. And / or utilized as an inhibitor of various polypeptides and other proteins that are otherwise inhibited. In particular, this description contains a ligand that binds to cereblon E3 ubiquitin ligase at one end and the target protein at the other end so that the target protein is located close to the ubiquitin ligase and results in degradation (and inhibition) of that protein. Provided are compounds that include a moiety that binds to. Compounds with a wide range of pharmacological activity consistent with the degradation / inhibition of almost all types of target polypeptides can be synthesized. |
| priorityDate | 2018-01-26^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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