| abstract |
Compounds effective in activating Tie-2 and inhibiting HPTP-beta are disclosed herein. These compounds provide effective treatment for diabetic nephropathy, eg, conditions associated with diabetic nephropathy due to hyperglycemia, renal hyperfiltration, renal injury, glycation products and cytokine activation. obtain. The present disclosure provides a method of treating nephropathy in a subject in need of treatment of nephropathy, wherein the method is a therapeutically effective amount of a Tie-2 activating compound or pharmaceutically acceptable thereof. It involves administering the salt to the subject. |