http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4648894-B2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D411-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D411-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 2004-02-27^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-03-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-03-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-4648894-B2 |
| titleOfInvention | Compounds and methods of treating cell proliferative diseases, retinopathy and arthritis |
| abstract | Quinoline derivatives (I) and their tautomers, optical and geometrical isomers, racemates, salts, hydrates or mixtures are new. Quinoline derivatives of formula (I) and their tautomers, optical and geometrical isomers, racemates, salts, hydrates or mixtures are new. [Image] R 1pyran derivative of formula (a1), piperdine derivative of formula (a2), dihydropyrrole derivative of formula (a3), alkane derivative of formula (a4) or amine derivative of formula (a5); R 2H, 3-6C alkyl or 3-6C alkenyl; B : halo, preferably chlorine, hydroxyl, O-CH 2-O-CH 3(MOM), O-CH 2-O-CH 2-CH 2-O-CH 3(MEM), OSO 2-alkyl or OSi(CH 3) 2tBu; D : O, NR 3, CR'R'' or S; X, Y : O, S or a radical NR 4; R 3H, alkyl, carboxylate, acyl, carboxamide or SO 2-alkyl; R', R'' : H or alkyl radical; R 4H, 1-10C alkyl, aryl or aralkyl; linker : (CH 2) n; n : 1-10; (optionally interrupted by an heteroatom (preferably N, O , S and P) or a carbonyl group, or an aryldialkyl (preferably xylenyl); and A : quinoline derivative of formulae (a6-a7), benzopyrimidine derivative of formula (a8) or benzothiophene derivative of formula (a9) (all optionally substituted). [Image] ACTIVITY : Cytostatic; Antiangiogenic; Vasotropic; Antiarthritic; Antidiabetic; Ophthalmological. MECHANISM OF ACTION : None given. |
| priorityDate | 2003-02-28^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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