| abstract |
NEW MATERIAL:A compound shown by formula I [R 1 is H, 1-14C alkyl, (halogen-substituted)benzyl, cinnamyl, naphthoxyethyl or (halogen-substituted) phenoxyethyl; R 2 is H or 1H-imidazolyl-1-yl; R 3 is H or (halogen-substituted) phenyl] or an acid addition salt thereof. n EXAMPLE: 5-(1H-imidazol-1-yl)-6-phenyl-3(2H)-pyridazinone. n USE: A drug useful as antithrombotic drug and antifungal agent having low toxicity and effective as a preventive and remedy of cerebral thrombosis, cerebral embolism, peripheral arterial and venous embolism and mycotic infection. n PREPARATION: For example, a 5-chloro-6-phenyl-3(2H)-pyridazinone derivative shown by formula II (R 4 and R 5 are H or Cl) is reacted with an excess amount of imidazole preferably in a solvent at 50-180°C for 1-8hr to give a compound shown by formula I wherein R 1 is H and R 3 is (halogen-substituted) phenyl. n COPYRIGHT: (C)1989,JPO&Japio |