| abstract |
NEW MATERIAL:1-Aryl-4-(1H-imidazol-1-yl)phthalazine derivative or formula I (R is lower alkoxyphenyl, allyloxyphenyl, pyridylmethyloxyphenyl, benzyloxyphenyl, furil which may have substituent, thienyl or naphthyl). n EXAMPLE: 1-(1H-imidazol-1-yl)-4-(4-ethoxyphenyl)phthalazine. n USE: Useful as a platelet aggregation inhibitor with high safety excellent in effect and capable of oral and parenteral administrations. n PREPARATION: For example various alkyl halide derivatives are reacted with a compound of formula II i n an amount of equimolar-two time moles of that of the compound using a basic compound as a dehalogenation agent at room temperature - 50°C as shown by the reaction formula to obtain the objective compound of formula I. n COPYRIGHT: (C)1990,JPO&Japio |