| abstract |
NEW MATERIAL: A compd. represented by formula I [wherein X is O, S or CH=CH, Z is OR 1 or NR 4 R 5 , R 1 is H, lower alkyl or a cation, R 2 is H, CH 3 or C 2 H 5 , R 3 is H, OH or O, R 4 and R 5 are H, 1-6C alkyl or combined together with N to form a group represented by formula II (n; 4 or 5) and m is 0-4] and a salt thereof. n EXAMPLE: Methyl 2-(5-hydroxy-1E,5E-tridecadienyl)-δ-oxobenzenepentanoate. n USE: Leucotriene B 4 antagonist useful for the treatment of an inflammatory disease in mammal, for example, psoriasis, clone disease or ulcerative colitis. n PROCESS: For example, a compd. represented by formula III derived from 5-(2- bromophenyl)-4-pentinic acid and a compd. represented by formula IV derived from 1-(trimethylsilyl)-1-undecyn-3-one are reacted to obtain a compd. represented by formula V and a protective group THP is removed from this compd. to obtain the exemplified compd. n COPYRIGHT: (C)1990,JPO |