| abstract |
NEW MATERIAL:A compound expressed by formula I {R 1 is cycloalkyl, alkyl, alkenyl, phenyl, etc.; R 2 is H, SH or alkylthio; R 3 is OH, OR 10 (R 10 is carboxy- protecting group), etc.; R 2 and R 3 together may be -NH-S; R 4 is H, halogen, OH, alkyl, etc.; R 5 is halogen, OH or alkoxy; R 6 to R 9 are H, halogen, alkyl, cycloalkyl, aryl, etc.; X is N or CY [Y is H, halogen, alkyl, etc., or together with R 1 , represents formula II or III (A is O, S, CH 2 , etc.; B is H, alkyl, aryl, etc.; R 11 to R 14 are H, alkyl, heterocyclic group, etc.); n is 0 or 1]}. n EXAMPLE: 7-(2-Isoindolinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4oxoquinoline-3- carboxylic acid. n USE: An antimicrobial agent. n PREPARATION: A compound expressed by formula IV (Z is reactive leaving group) is condensed with a compound expressed by formula V and, as necessary, hydrolyzed to afford the compound expressed by formula I. n COPYRIGHT: (C)1990,JPO&Japio |