| abstract |
PURPOSE: To obtain the subject compound useful as anticancer drug or intermediate of said drug in high yield and high purity by reacting chartreusin with acyl halide in the presence of strong basic substance having dehydrohalogenating action. n CONSTITUTION: Chartreusin or 3',4'-O-benzylidene chartreusin is reacted with acyl halide in the presence of strong basic substance having dehydrohalogenating action (preferably triethylamine or 1,8-diazabicyclo[5.4.0]undecene-7) to obtain the aimed compound. Besides, chartreusin is usually dissolved in solvent such as benzene, etc., and basic substance is added, then acyl halide is added, thus the reaction is performed. Further, reaction temperature is preferably from from -5°C to 30°C. n COPYRIGHT: (C)1990,JPO&Japio |