| abstract |
NEW MATERIAL:A compound shown by formula I {A is group shown by formula II [X is H, halogen or nitro; R 1 is -X 1 Z 1 (X 1 is O or S; Z 1 is alkyl or alkenyl), -COZ 1 , etc.; R 3 is nitro, etc.]; R is group shown by formula II (R 8 is as shown for Y; q is 1-4), etc.; Y is halogen, alkyl, alkoxy, etc.} or a salt thereof. n EXAMPLE: Methyl 4-[4-(5-bromo-2-pyrimidinyloxy)-3-chlorophenyl]-7-(2-,- nitrophenyl)-2-octyl-5,7-dioxo-3-thia-2,4,6-triazaheptanate. n USE: An anti-cancer drug useful for treating cancers such as leukemia, melanoma, sarcoma or carcinoma. n PREPARATION: A compound shown by formula IV (A 1 is -HCH or -NH 2 ) is reacted with a compound shown by formula V (A 2 is H or -COCl) in a solvent such as benzene in the presence of a base (e.g., triethylamine) at 0°C - reflux temperature to give a compound shown by formula I. n COPYRIGHT: (C)1990,JPO&Japio |