| abstract |
NEW MATERIAL:The compound of formula I [R 1 is H, lower alkyl, lower alkenyl, lower alkynyl, lower hydroxyalkyl, R 3 -CO- (R 3 is lower alkyl, phenyl, etc.), etc.; R 2 is H, lower alkyl, lower alkoxy-lower alkyl, phenyl, etc.; Y is cyano, halogen, nitro, lower alkyl, carboxyl, morpholinocarbonyl, etc.]. n EXAMPLE: 6-Cyano-2,2-dimethyl-4-[(N-cyano-formimidoyl)amino]-2H-benzo[b]pyran. n USE: It has excellent potassium-channel activation effect and is useful as a hypotensor and bronchodilator. n PREPARATION: The objective compound can be produced by reacting a compound of formula II (R 1 is a group defined above excluding the group R 3 -CO-) with a compound of formula R 4 SO 2 X (e.g. methanesulfonyl chloride) and treating the resultant compound of formula III with a base. n COPYRIGHT: (C)1991,JPO&Japio |