abstract |
NEW MATERIAL:A 1,6-dihydro-6-oxo-2-phenoxyalkyltio-5-pyrimidine carboxylic acid or a salt thereof, wherein, in formula I, R 1 and R 2 are H, lower alkoxy, lower alkylthio, lower alkyl, lower alkoxycarbonyl, halogen, di(lower alkylamino), lower acylamino, hydroxy, lower acyl, nitro; R 2 is H, ethyl; and (n) is 2-6. n EXAMPLE: 2-(2-Phenoxyethyltio)-1,6-dihydro-6-oxo-5-pyrimidine carboxylic acid ethyl ester. n USE: A medicine useful for preventing and treating various allergic diseases or treating digestive ulcer. n PREPARATION: A compound of formula II is reacted with ethoxymethylene malonic diethyl ester in the presence of a base to prepare the compound of formula I as shown in the reaction equation. n COPYRIGHT: (C)1991,JPO&Japio |