| abstract |
(57) [Summary] [Structure] General Formula [Chemical Formula 13] [In the formula, R 1 is —OR 3 (R 3 is H, alkyl), —N R 4 R 5 (R 4 and R 5 are H, alkyl, alkoxy), —NHCH (R 6 ) COR 7 group (R 6 is H, alkyl, R 7 is alkyl), —NHCH (R 6 ) COOR 8 groups (R 8 is alkyl) or —NHCH (R 6 ) CON R 9 R 10 group (R 9 and R 10 are H, alkyl or NR 9 R 10 are together heterocycles): R 2 is a compound having H, alkyl or aralkyl). [Effect] Since the compound of the present invention has inhibitory activity against type IV collagenase, it is useful as an inhibitor of angiogenesis, cancer invasion or cancer metastasis. |