| abstract |
(57) [Summary] (Modified) [Constitution] Formula (VI) or (VII) Of the formula (II) or (III), characterized in that the α-hydroxycarboxylic acid derivative of the above is reacted with a trifluoromethane sulfonating agent in the presence or absence of a base. Of the compound of. (In the formula, R is alkyl, alkenyl, etc .: R 1 is hydrogen, and in some cases amino, etc .: R 2 , R 3 Represents hydrogen, alkyl, alkenyl, etc .: n is 1 or 2. [Effect] A trifluoromethanesulfonyloxycarboxylic acid derivative is an N-alkylated aminocarboxylic acid derivative useful as an angiotensin converting enzyme (ACE) inhibitor. It is useful as an intermediate. |