| abstract |
(57) [Summary] (Modified) [Objective] To provide an amination method of a sugar, which is a simple method to aminate a sugar to obtain an aminated sugar derivative. A method for easily producing an aminated sugar derivative having a single structure and a labeled form thereof from a mixture of sugars, or a method for producing an artificial glycoconjugate by reacting the aminated sugar derivative with another organic compound such as protein. provide. [Structure] An aminated sugar derivative represented by the following formula (b) is obtained by subjecting a 2-aminopyridine derivatized saccharide represented by the following formula (a) to a reduction reaction and then a decomposition reaction under alkaline conditions. A method for amination of sugars, which comprises: R—CH 2 —NH 2 (b) (In the formula, R—CH 2 — is a group derived from a saccharide which can be represented by R—CHO at the reducing terminal of which is aldehydized. R 1 , R 2 , R 3 and R. 4 represents hydrogen or a lower alkyl group) |