| abstract |
(57) [Summary] [Structure] General formula (In the formula, R 1 : an alkyl group, a cycloalkylalkyl group, an aralkyl group; R 2 : a protecting group for a carboxy group; R 4 , R 5 : H, a heterocyclic group; provided that R 4 and R 5 are simultaneously H Not shown. A compound having the general formula XCH 2 CO 2 R 6 (wherein X is a halogen atom; R 6 is a protecting group for a carboxy group) is condensed in the presence of a base to give a compound of the general formula (Wherein R 1 , R 2 , R 4 , R 5 , R 6 are as defined above), and the protecting group R 6 for the carboxy group of this compound is removed. , General formula: A method for producing a perhydro-1,4-thiazepine derivative having the formula (wherein R 1 , R 2 , R 4 , and R 5 are as defined above). [Effect] This compound has an angiotensin converting enzyme inhibitory action and is useful as an antihypertensive drug. |