| abstract |
(57) [Summary]n[Purpose] Expressionn[Chemical 1]n [Wherein R (1) is H, Hal, CN, NO 2 , (Cyclo) Alkyl or (O) (S) [NR (5)] (CH 2 ) b -(C F 2 ) c -CF 3 -SR (10), -OR (10) or- CR (10) R (11) R (12); naphthyl, (bi) phenyl (Il) or (C 1 ~ C 9 ) -Heteroaryl; -SR (13), -OR (13), -NHR (13), -NR (13) R (14), -CHR (13) R (15), -C [R (15) R (16)] OH, -C≡CR (18), -C [R (19)] = CR (18),-[CR (20) R (21)] k -(CO)- [CR (22) R (23) R (24)] l And R (2) and And R (3) have the same definition as R (1), and R (4) is an alkyl group. Le, Hal, CN or-(CH 2 ) n -(CF 2 ) o -CF 3 Ortho-substituted benzoylguanidine or And pharmaceutically acceptable salts thereof.n[Effects] The compound does not exhibit undesirable salt diuretic properties Is also useful as a therapeutic drug for arrhythmia, infarction and angina And the compound is cellular Na + / H + Inhibitory activity of alternate transport mechanism For all the injuries caused by ischemia due to its nature Is also useful as |