| abstract |
(57) [Summary] (Modified) [Objective] To provide an extracellular matrix metalloprotease inhibitor. [Structure] An extracellular matrix metalloprotease agent comprising a carbostyril derivative represented by the general formula (1) or a salt thereof as an active ingredient, and R 1 and R in the formula (1) 2 and R 5 are hydrogen, R 3 is a lower alkyl group, R 6 is a C 1 -C 12 alkyl group, R 4 is a lower alkylenedioxy group (particularly a methylenedioxy group, n is The compound which is 1. [In the formula, R 1 represents a hydrogen atom or the like. R 2 represents a hydrogen atom or the like. R 3 represents a hydrogen atom or the like. R 4 represents a hydrogen atom or the like. R 5 represents a hydrogen atom or the like. R 6 represents a lower alkyl group or the like. n represents 1 or 2. [Effect] The compound of the general formula (1) exhibits excellent stromelymin inhibitory activity and collagenase inhibitory activity, and can suppress metastatic invasion of tumor cells. |