http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0899924-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47cc435e1d443f13180f7766df104d9d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K19-08 |
| filingDate | 1994-09-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f95a83750759de4df8161bcf30888321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f069a643bf09f745b24f97eaad5f97c6 |
| publicationDate | 1996-04-16^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0899924-A |
| titleOfInvention | Optically active biphenyl alcohol derivative having difluoromethyl group, synthetic intermediate thereof, and production method thereof |
| abstract | (57) [Abstract] [PROBLEMS] To provide an optically active biphenyl alcohol derivative having a difluoromethyl group, a synthetic intermediate thereof, and a method for producing the same. [Structure] Optically active 2-difluoromethyl-2- (4'- Methoxybiphenyl) acetic acid is reacted with trimethylsilyldiazomethane to give its methyl ester, which is treated with boron tribromide to give methyl 2-difluoromethyl-2- (4'-hydroxybiphenyl) acetate, 3,4-dihydro-2H- 2-difluoromethyl-2 by reacting with pyran -(4'-Tetrahydropyranyloxybiphenyl) methyl acetate and reduced with lithium aluminum hydride to 2-difluoromethyl-2- (4'-tetrahydropyranyloxybiphenyl) ethanol, sodium hydride and hexyl iodide To hexyloxylate and treat with pyridinium paratoluenesulfonate to give 2-difluoromethyl-2- (4′-hydroxybiphenyl) -1-hexoxyethane. |
| priorityDate | 1994-09-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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