| abstract |
(57) [Summary] [Structure] A compound of formula (I) and a salt thereof (in the formula, R 1 , R 2 is H, an alkyl group or the like; E is —CONR 3 —, —NR 3 CO -, - COO -, - OCO -, - NR 3 CONR 3 -, - COCH 2 -, - CO -, - OCONR 3 -, - NR 3 COO -, - OCOO - , - CSNR 3 -, - NR 3 CS-, -NR 3 CSNR 3- , -OCSNR 3- , -N R 3 CSO -, - CSO - , - OCS -, - OCSO -; J is a single bond, alkylene, alkenylene, group of formula (II), A is H, alkyl, cycloalkyl, Ar group, G is - (CH 2) m -, a group of formula (III)). Embedded image [Effect] The compound of formula (I) has a gelatinase inhibitory action, and has rheumatism, osteoarthritis, pathological bone resorption, osteoporosis, Periodontal disease, interstitial nephritis, arteriosclerosis, emphysema, liver cirrhosis, corneal damage, cancer cell metastasis invasion and proliferation disease, autoimmune disease, leukocyte cell migration and invasion disease, angiogenesis prevention And / or is useful in therapy. |