| abstract |
(57) [Summary] (Modified) [Problem] To provide a piperidine derivative for use in healing in pathological phenomena including tachykinin system. Kind Code: A1 Piperazine derivatives represented by the compounds of formula (I "" a) and formula (I "" b), methods for producing them, and pharmaceutical compositions containing them. [In the formula, A ′ represents a direct bond or —CH 2 —, Z′a Represents a phenyl group which may be substituted with halogen or C 1 -C 10 alkoxy at the 3-position, Z′b represents phenyl, 3,5- or 2,4-bis (trifluoromethyl) phenyl, 3,5 -Represents dimethylphenyl, R 13 , R 17 and R 18 represent a hydrogen atom and C 1 -C 7 alkyl, and R 18 represents C 3 -C 7 cycloalkyl, phenyl, Represents benzyl and the like, q is 0, 1, 2] [Effect] The compound has a neurokinin receptor antagonistic activity, and is useful for healing all substance p- and neurokinin dependences. |