http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H09510458-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16022 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16122 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16 |
| filingDate | 1995-03-15^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1997-10-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H09510458-A |
| titleOfInvention | Peptide vaccine and methods related thereto |
| abstract | (57) [Summary]nPeptide vaccines and related methods for generating protective immune responses in warm-blooded animals are disclosed. Peptide vaccines are dividable by covalently linking conformationally constrained reverse turn pseudo-forms, T cell stimulating peptides and conformationally constrained reverse turn pseudo-forms and T cell stimulating peptides. Contains a linker molecule. A conformationally constrained reverse-turn pseudo-form is capable of pseudo-determining the three-dimensional structure of the antigenic determinant of the native pathogenic protein and binding to B cells. Upon binding to B cells, the peptide vaccine is taken up intracellularly and cleavage of the cleavable linker releases the T cell stimulating peptide from the conformationally constrained reverse turn pseudo-form. The T cell stimulating peptide is then associated with class I or II MHC molecules and presented on the surface of B cells, inducing T cell activation and producing a protective immune response. |
| priorityDate | 1994-03-15^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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