| abstract |
(57) [Summary] Compounds represented by the general formula (I) and salts thereof (wherein, R 1 is alkyl, alkoxy, etc .; D ring is carbocycle, heterocycle; R 2 and R 3 are H, alkyl such as; R 4 is alkyl, alkoxy or the like; R 5 and R 6 are H, -OH, alkyl, -M-R 16, an alkyl group substituted with one or two of oR 27, -J-COOR 29 Or R 5 and R 6 are heterocyclic with N to which they are attached; R 15 is OH, alkyl, —COOR 36 , —NR 43 R 44 , —CONR 45 R 46 , a heterocyclic ring and the like. ). Embedded image [Effect] The compound of the formula (I) has an elastase inhibitory effect, and the effect can be particularly obtained by oral administration. Therefore, the compound of the general formula (I) and a salt thereof are used for treating and / or preventing emphysema, rheumatoid arthritis, atherosclerosis, adult respiratory distress (ARDS), myocardial infarction, ulcerative colitis, periodontal disease and the like. Useful for |