abstract |
(57) [Summary]nThe present invention relates to sulfonamides containing THF which are aspartyl protease inhibitors. The present invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of the invention are particularly well-suited for inhibiting HIV-1 and HIV-2 protease activity, which makes them antiviral agents against HIV-1 and HIV-2 viruses. Can be used advantageously. The present invention also relates to a method of inhibiting HIV aspartyl protease activity using a compound of the present invention. |