| abstract |
(57) Abstract: Useful for preventing or reducing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with neoplastic diseases, bacterial and fungal infections, and Alzheimer's disease, and thus for the treatment of Alzheimer's disease Useful is a compound of formula (I) wherein X is carbonyl, sulfonyl, methylene or methylene substituted with an optionally substituted phenyl; Z is nitrogen or CH; and Ar 1 and Ar 2 are independently Y represents hydrogen; or Y and R 1 or R 2 represent CH 2 ; CH 2 CH 2 ; CH 2 O; CH 2 S which together form a 5- or 6-membered ring; Such a ring may be optionally substituted with lower alkyl or phenyl) or a pharmaceutically acceptable salt thereof. |