| abstract |
(57) [Summary]nThe present invention relates to adenosine kinase inhibitors and nucleoside analogs, in particular, C-4′-modified pyrrolo [2,3-d] pyrimidines and pyrazolo [3,4-d] pyrimidines having activity as adenosine kinase inhibitors It relates to nucleoside analogs. The present invention relates to nucleoside analogs having no or two substituents at the C-4 'position of the furanose (sugar) moiety. The invention also relates to the preparation of these adenosine kinase inhibitors and their use in the treatment of cardiovascular and cerebrovascular diseases, inflammation, and other diseases that can be modulated by increasing local concentrations of adenosine. |