http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S63162654-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f8cfa5aee4410611b5c562275c9f8e3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J27-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-487 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| filingDate | 1986-12-26^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc61188ec6d6fefc25a318c2d1128ea8 |
| publicationDate | 1988-07-06^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S63162654-A |
| titleOfInvention | Production of alpha-phenylpropionic acid derivative |
| abstract | PURPOSE: To improve purity readily in obtaining the titled compound as a drug by adding an extracting solvent to a reaction product of an α-phenylethyl alcohol derivative and carbon monoxide and separating the solution into two phases, by adding an alkali aqueous solution to an upper phase. n CONSTITUTION: An α-phenylethyl alcohol derivative shown by formula I (R is H, alkyl, alkenyl or aryl) is reacted with carbon monoxide in the presence of a rhodium catalyst and an iodine compound in a solvent such as preferably 1,4-dioxane, etc., at 30W130°C to give a reaction solution containing an α- phenylpropionic acid derivative shown by formula II. Then the reaction solution is incorporated with water or water and an oxygen-containing organic compound (e.g. acetic acid, etc.) as an extracting solvent and separated into two phases. An upper phase solution after the separation is mixed with an alkali aqueous solution, the compound shown by formula II is extracted as an alkali salt in the aqueous solution and further mixed with an acid to isolate the aimed compound. n COPYRIGHT: (C)1988,JPO&Japio |
| priorityDate | 1986-12-26^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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